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YKu70/YKu80 is a heterodimer that is essential for repair of DNA double strand breaks through non-homologous end joining pathway in the yeast  Saccharomyces cerevisiae . Yku70/80 proteins are associated with telomeres and are important for maintaining the integrity of telomeres. These proteins protect telomeres from recombination events, nuclease attacks, support the formation of heterochromatin at telomeres and anchor telomeres to the nuclear periphery. To identify components in molecular networks involved in the multiple functions of Yku70/80 complex, we performed a genetic screen for suppressors of  yku70  deletion. One of the suppressors identified was  RTT103 , which encodes a protein implicated in transcription termination. We show that  rtt103 Δ are sensitive to multiple forms of genome insults and that  RTT103  is essential for recovery from DNA double strand breaks in the chromosome. We further show that Rtt103 associates with sites of DNA breaks and hence is likely to play a direct role in response to DNA damage.

Yeast Transcription Termination Factor Rtt103 Functions in DNA Damage Response