English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  This study aimed to determine the association of lipoprotein-associated phospholipase A 2  (Lp-PLA 2 ) activity in circulation and peripheral blood mononuclear cells (PBMCs) with inflammatory and oxidative stress markers in nonobese women and according to menopausal status. Lp-PLA 2  activity, a marker for cardiovascular risk is associated with inflammation and oxidative stress.    Methodology/Principal Findings  Eighty postmenopausal women (53.0±4.05 yr) and 96 premenopausal women (39.7±9.25 yr) participated in this study. Lp-PLA 2  activities, interleukin (IL)-6, tumor necrosis factor (TNF)-α, and IL-1β in plasma as well as in PBMCs were measured. Plasma ox-LDL was also measured. Postmenopausal women demonstrated higher circulating levels of ox-LDL and IL-6, as well as IL-6, TNF-α, and IL-1β in PBMCs, than premenopausal women. In both groups, plasma Lp-PLA 2  activity positively correlated with Lp-PLA 2  activity in PBMCs and plasma ox-LDL. In premenopausal women, Lp-PLA 2  activities in plasma and PBMCs positively correlated with IL-6, TNF-α, and IL-1β in PBMCs. In postmenopausal women, plasma ox-LDL positively correlated with PBMC cytokine production. In subgroup analysis of postmenopausal women according to plasma ox-LDL level (median level: 48.715 U/L), a significant increase in Lp-PLA 2  activity in the plasma but not the PBMCs was found in the high ox-LDL subgroup. Plasma Lp-PLA 2  activity positively correlated with unstimulated PBMC Lp-PLA 2  activity in the low ox-LDL subgroup (r = 0.627, P<0.001), whereas in the high ox-LDL circulating Lp-PLA 2  activity positively correlated with plasma ox-LDL (r = 0.390, P = 0.014) but not with Lp-PLA 2  activity in PBMCs.    Conclusions/Significance  The lack of relation between circulating Lp-PLA 2  activity and Lp-PLA 2  activity in PBMCs was found in postmenopausal women with high ox-LDL. This may indicate other sources of circulating Lp-PLA 2  activity except PBMC in postmenopausal women with high ox-LDL. We also demonstrated that circulating Lp-PLA 2  and PBMC secreted Lp-PLA 2  associate differently with markers of oxidative stress and sub clinical inflammation in nonobese women, particularly according to the menopausal states.

Circulating and PBMC Lp-PLA2 Associate Differently with Oxidative Stress and Subclinical Inflammation in Nonobese Women (Menopausal Status)