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Peripheral T cell lymphomas (PTCLs) are associated with a poor prognosis due to often advanced disease at the time of diagnosis and due to a lack of efficient therapeutic options. Therefore, appropriate animal models of PTCL are vital to improve clinical management of this disease. Here, we describe a monoclonal CD8 +  CD4 −  αβ T cell receptor Vβ2 +  CD28 +  T cell lymphoma line, termed T8-28. T8-28 cells were isolated from an un-manipulated adult BALB/c mouse housed under standard pathogen-free conditions. T8-28 cells induced terminal malignancy upon adoptive transfer into syngeneic BALB/c mice. Despite intracellular expression of the cytotoxic T cell differentiation marker granzyme B, T8-28 cells appeared to be defective with respect to cytotoxic activity as read-out  in vitro.  Among the protocols tested, only addition of interleukin 2  in vitro  could partially compensate for the  in vivo  micro-milieu in promoting growth of the T8-28 lymphoma cells.

Characterization of a New Mouse Model for Peripheral T Cell Lymphoma in Humans