English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Juvenile hormone (JH) plays key roles in controlling insect growth and metamorphosis. However, relatively little is known about the JH signaling pathways. Until recent years, increasing evidence has suggested that JH modulates the action of 20-hydroxyecdysone (20E) by regulating expression of  broad  ( br ), a 20E early response gene, through Met/Gce and Kr-h1. To identify other genes involved in JH signaling, we designed a novel  Drosophila  genetic screen to isolate mutations that derepress JH-mediated  br  suppression at early larval stages. We found that mutations in three Wnt signaling negative regulators in  Drosophila ,  Axin  ( Axn ),  supernumerary limbs  ( slmb ), and  naked cuticle  ( nkd ), caused precocious  br  expression, which could not be blocked by exogenous JHA. A similar phenotype was observed when  armadillo  ( arm ), the mediator of Wnt signaling, was overexpressed. qRT-PCR revealed that  Met ,  gce  and  Kr-h1 expression was suppressed in the  Axn ,  slmb  and  nkd  mutants as well as in  arm  gain-of-function larvae. Furthermore, ectopic expression of  gce  restored  Kr-h1  expression but not  Met  expression in the  arm  gain-of-function larvae. Taken together, we conclude that Wnt signaling cross-talks with JH signaling by suppressing transcription of  Met  and  gce , genes that encode for putative JH receptors. The reduced JH activity further induces down-regulation of  Kr-h1 expression and eventually derepresses  br  expression in the  Drosophila  early larval stages.

Wnt Signaling Cross-Talks with JH Signaling by Suppressing Met and gce Expression