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Dendritic cells (DCs) subsets differ in precursor cell of origin, functional properties, requirements for growth factors, and dependence on transcription factors. Lymphoid-tissue resident CD8α +  conventional DCs (cDCs) and CD11b low/− CD103 +  non-lymphoid DCs are developmentally related, each being dependent on FMS-like tyrosine kinase 3 ligand (Flt3L), and requiring the transcription factors  Batf3 ,  Irf8 , and  Id2  for development. It was recently suggested that granulocyte/macrophage colony stimulating factor (GM-CSF) was required for the development of dermal CD11b low/− Langerin + CD103 +  DCs, and that this dermal DC subset was required for priming autoreactive T cells in experimental autoimmune encephalitis (EAE). Here, we compared development of peripheral tissue DCs and susceptibility to EAE in GM-CSF receptor deficient ( Csf2rb   −/− ) and  Batf3   −/−  mice. We find that  Batf3 -dependent dermal CD11b low/− Langerin +  DCs do develop in  Csf2rb   −/−  mice, but that they express reduced, but not absent, levels of CD103. Further,  Batf3   −/−  mice lacking all peripheral CD11b low/−  DCs show robust Th cell priming after subcutaneous immunization and are susceptible to EAE. Our results suggest that defective T effector priming and resistance to EAE exhibited by  Csf2rb   −/−  mice does not result from the absence of dermal CD11b low/− Langerin + CD103 +  DCs.

Batf3-Dependent CD11blow/− Peripheral Dendritic Cells Are GM-CSF-Independent and Are Not Required for Th Cell Priming after Subcutaneous Immunization