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Background    MYCT1 , a putative target of c-Myc, is a novel candidate tumor suppressor gene cloned from laryngeal squamous cell carcinoma (LSCC). Its transcriptional regulation and biological effects on LSCC have not been clarified.    Methodology/Principal Findings  Using RACE assay, we cloned a 1106 bp transcript named Myc target 1 transcript variant 1 ( MYCT1-TV ) and confirmed its transcriptional start site was located at 140 bp upstream of the ATG start codon of  MYCT1-TV . Luciferase, electrophoretic mobility shift and chromatin immunoprecipitation assays confirmed c-Myc could regulate the promoter activity of  MYCT1-TV  by specifically binding to the E-box elements within −886 to −655 bp region. These results were further verified by site-directed mutagenesis and RNA interference (RNAi) assays.  MYCT1-TV  and  MYCT1  expressed lower in LSCC than those in paired adjacent normal laryngeal tissues, and overexpression of  MYCT1-TV  and  MYCT1  could inhibit cell proliferation and invasion and promote apoptosis in LSCC cells.    Conclusions/Significance  Our data indicate that  MYCT1-TV , a novel  MYCT1  transcript, is regulated by c-Myc and down-regulation of  MYCT1-TV/MYCT1  could contribute to LSCC development and function.

MYCT1-TV, A Novel MYCT1 Transcript, Is Regulated by c-Myc and May Participate in Laryngeal Carcinogenesis