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Background  Knowledge of seasonal trends in hospital-associated infection incidence may improve surveillance and help guide the design and evaluation of infection prevention interventions. We estimated seasonal variation in the frequencies of inpatient bloodstream infections (BSIs) caused by common bacterial pathogens and examined associations of monthly BSI frequencies with ambient outdoor temperature, precipitation, and humidity levels.    Methods  A database containing blood cultures from 132 U.S. hospitals collected between January 1999 and September 2006 was assembled. The database included monthly counts of inpatient blood cultures positive for several clinically important Gram-negative bacteria ( Acinetobacter  spp,  Escherichia coli ,  Klebsiella pneumoniae , and  Pseudomonas aeruginosa ) and Gram-positive bacteria ( Enterococcus  spp and  Staphylococcus aureus ). Monthly mean temperature, total precipitation, and mean relative humidity in the postal ZIP codes of participating hospitals were obtained from national meteorological databases.    Results  A total of 211,697 inpatient BSIs were reported during 9,423 hospital-months. Adjusting for long-term trends, BSIs caused by each Gram-negative organism examined were more frequent in summer months compared with winter months, with increases ranging from 12.2% for  E. coli  (95% CI 9.2–15.4) to 51.8% for  Acinetobacter  (95% CI 41.1–63.2). Summer season was associated with 8.7% fewer  Enterococcus  BSIs (95% CI 11.0–5.8) and no significant change in  S. aureus  BSI frequency relative to winter. Independent of season, monthly humidity, monthly precipitation, and long-term trends, each 5.6°C (10°F) rise in mean monthly temperature corresponded to increases in Gram-negative bacterial BSI frequencies ranging between 3.5% for  E. coli  (95% CI 2.1–4.9) to 10.8% for  Acinetobacter  (95% CI 6.9–14.7). The same rise in mean monthly temperature corresponded to an increase of 2.2% in  S. aureus  BSI frequency (95% CI 1.3–3.2) but no significant change in  Enterococcus  BSI frequency.    Conclusions  Summer season and higher mean monthly outdoor temperature are associated with substantially increased frequency of BSIs, particularly among clinically important Gram-negative bacteria.

Seasonal and Temperature-Associated Increases in Gram-Negative Bacterial Bloodstream Infections among Hospitalized Patients