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Metabolic gene clusters—functionally related and physically clustered genes—are a common feature of some eukaryotic genomes. Two hypotheses have been advanced to explain the origin and maintenance of metabolic gene clusters: coordinated gene expression and genetic linkage. Here we test the hypothesis that selection for coordinated gene expression underlies the clustering of  GAL  genes in the yeast genome. We find that, although clustering coordinates the expression of  GAL1  and  GAL10 , disrupting the  GAL  cluster does not impair fitness, suggesting that other mechanisms, such as genetic linkage, drive the origin and maintenance metabolic gene clusters.

A Test of the Coordinated Expression Hypothesis for the Origin and Maintenance of the GAL Cluster in Yeast