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Pseudomonas aeruginosa  is a threatening, opportunistic pathogen causing disease in immunocompromised individuals. The hallmark of  P. aeruginosa  virulence is its multi-factorial and combinatorial nature. It renders such bacteria infectious for many organisms and it is often resistant to antibiotics. To gain insights into the physiology of  P. aeruginosa  during infection, we assessed the transcriptional programs of three different  P. aeruginosa  strains directly after isolation from burn wounds of humans. We compared the programs to those of the same strains using two infection models: a plant model, which consisted of the infection of the midrib of lettuce leaves, and a murine tumor model, which was obtained by infection of mice with an induced tumor in the abdomen. All control conditions of  P. aeruginosa  cells growing in suspension and as a biofilm were added to the analysis. We found that these different  P. aeruginosa  strains express a pool of distinct genetic traits that are activated under particular infection conditions regardless of their genetic variability. The knowledge herein generated will advance our understanding of  P. aeruginosa  virulence and provide valuable cues for the definition of prospective targets to develop novel intervention strategies.

In-Vivo Expression Profiling of Pseudomonas aeruginosa Infections Reveals Niche-Specific and Strain-Independent Transcriptional Programs