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Background and Objectives  Glutathione S-transferases (GSTs) are multifunctional enzymes that play a key role in the detoxification of varieties of both endogenous products of oxidative stress and exogenous carcinogens.    Methods  In this meta-analysis, twenty-five studies were identified by searching PubMed, EMBASE, ISI Web of Science and CBM databases: 23 evaluated  GSTM1  and 19 evaluated  GSTT1 . Crude odds ratios with corresponding 95% confidence intervals were used to estimate the association between  GSTM1  and  GSTT1  polymorphisms and risk of cervical neoplasia. Subgroup analyses were conducted by pathological history, ethnicity, source of DNA for genotyping, quality score, and matching variable.    Results  The null genotypes of  GSTM1  and  GSTT1  polymorphisms were associated with a significantly increased risk of cervical neoplasia (for  GSTM1 : OR = 1.40; 95%CI, 1.19–1.65; for  GSTT1 : OR = 1.30; 95%CI, 1.05–1.62, respectively). Subgroup analyses showed that the null genotype of  GSTM1  increased the risk of cervical neoplasia in Asians, studies with DNA isolation from white blood cells and tissue samples, both high and low quality studies, and matched studies. In  GSTM1 - GSTT1  interaction analysis, individuals with dual null genotype were associated with a significantly increased risk of cervical neoplasia (OR = 1.72; 95%CI, 1.18–2.51).    Conclusion  These findings indicate that  GSTM1  and  GSTT1  polymorphisms, particularly  GSTM1 - GSTT1  interaction, may play critical roles in the development of cervical neoplasia. A conservative manner should be adopted to interpret these results because of obvious heterogeneity between-study, unadjusted data, and relatively small sample size in this meta-analysis. Well designed studies with larger sample size are of great value to confirm these results.

Null Genotypes of GSTM1 and GSTT1 Contribute to Risk of Cervical Neoplasia: An Evidence-Based Meta-Analysis