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Background  Understanding the structure of complex networks is a continuing challenge, which calls for novel approaches and models to capture their structure and reveal the mechanisms that shape the networks. Although various topological measures, such as degree distributions or clustering coefficients, have been proposed to characterize network structure from many different angles, a comprehensive and intuitive representation of large networks that allows quantitative analysis is still difficult to achieve.    Methodology/Principal Findings  Here we propose a mesoscopic description of large networks which associates networks of different structures with a set of particular curves, using breadth-first search. After deriving the expressions of the curves of the random graphs and a small-world-like network, we found that the curves possess a number of network properties together, including the size of the giant component and the local clustering. Besides, the curve can also be used to evaluate the fit of network models to real-world networks. We describe a simple evaluation method based on the curve and apply it to the  Drosophila melanogaster  protein interaction network. The evaluation method effectively identifies which model better reproduces the topology of the real network among the given models and help infer the underlying growth mechanisms of the  Drosophila  network.    Conclusions/Significance  This curve-shaped description of large networks offers a wealth of possibilities to develop new approaches and applications including network characterization, comparison, classification, modeling and model evaluation, differing from using a large bag of topological measures.

A Curve Shaped Description of Large Networks, with an Application to the Evaluation of Network Models