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Background  In the intestine, the integrin CD103 is expressed on a subset of T regulatory (T reg ) cells and a population of dendritic cells (DCs) that produce retinoic acid and promote immune homeostasis. However, the role of CD103 during intestinal helminth infection has not been tested.    Methodology/Principal Findings  We demonstrate that CD103 is dispensable for the development of protective immunity to the helminth parasite  Trichuris muris . While we observed an increase in the frequency of CD103 +  DCs in the lamina propria (LP) following acute high-dose infection with  Trichuris , lack of CD103 had no effect on the frequency of CD11c +  DCs in the LP or mesenteric lymph nodes (mLN). CD103-deficient (CD103 −/− ) mice develop a slightly increased and earlier T cell response but resolve infection with similar kinetics to control mice. Similarly, low-dose chronic infection of CD103 −/−  mice with  Trichuris  resulted in no significant difference in immunity or parasite burden. Absence of CD103 also had no effect on the frequency of CD4 + CD25 + Foxp3 +  T reg  cells in the mLN or LP.    Conclusions/Significance  These results suggest that CD103 is dispensable for intestinal immunity during helminth infection. Furthermore, lack of CD103 had no effect on DC or T reg  recruitment or retention within the large intestine.

Assessing the Role of CD103 in Immunity to an Intestinal Helminth Parasite