English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Pulmonary exposure to  Aspergillus fumigatus  has been associated with morbidity and mortality, particularly in immunocompromised individuals.  A. fumigatus  conidia produce β-glucan, proteases, and other immunostimulatory factors upon germination. Murine models have shown that the ability  of A. fumigatus  to germinate at physiological temperature may be an important factor that facilitates invasive disease. We observed a significant increase in IFN-γ-producing CD8 +  T cells in bronchoalveolar lavage fluid (BALF) of immunocompetent mice that repeatedly aspirated  A. fumigatus  conidia in contrast to mice challenged with  A. versicolor , a species that is not typically associated with invasive, disseminated disease. Analysis of tissue sections indicated the presence of germinating spores in the lungs of mice challenged with  A. fumigatus , but not  A. versicolor . Airway IFN-γ + CD8 +  T-cells were decreased and lung germination was eliminated in mice that aspirated  A. fumigatus  conidia that were formaldehyde-fixed or heat-inactivated. Furthermore,  A. fumigatus  particles exhibited greater persistence in the lungs of recipient mice when compared to non-viable  A. fumigatus  or  A. versicolor , and this correlated with increased maintenance of airway memory-phenotype CD8 +  T cells. Therefore, murine airway CD8 +  T cell-responses to aspiration of  Aspergillus  conidia may be mediated in part by the ability of conidia to germinate in the host lung tissue. These results provide further evidence of induction of immune responses to fungi based on their ability to invade host tissue.

Role of Germination in Murine Airway CD8+ T-Cell Responses to Aspergillus Conidia