English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Sulfated polysaccharides from  Laminaria saccharina  (new name:  Saccharina latissima ) brown seaweed show promising activity for the treatment of inflammation, thrombosis, and cancer; yet the molecular mechanisms underlying these properties remain poorly understood. The aim of this work was to characterize, using  in vitro  and  in vivo  strategies, the anti-inflammatory, anti-coagulant, anti-angiogenic, and anti-tumor activities of two main sulfated polysaccharide fractions obtained from  L. saccharina: a)   L.s.-1.0  fraction mainly consisting of O-sulfated mannoglucuronofucans and  b )  L.s.-1.25  fraction mainly composed of sulfated fucans. Both fractions inhibited leukocyte recruitment in a model of inflammation in rats, although  L.s.-1.25  appeared to be more active than  L.s.-1.0 . Also, these fractions inhibited neutrophil adhesion to platelets under flow. Only fraction  L.s.-1.25 , but not  L.s.-1.0 , displayed anticoagulant activity as measured by the activated partial thromboplastin time. Investigation of these fractions in angiogenesis settings revealed that only  L.s.-1.25  strongly inhibited fetal bovine serum (FBS) induced  in vitro  tubulogenesis. This effect correlated with a reduction in plasminogen activator inhibitor-1 (PAI-1) levels in  L.s.-1.25 -treated endothelial cells. Furthermore, only parent sulfated polysaccharides from  L. saccharina  ( L.s.-P ) and its fraction  L.s.-1.25  were powerful inhibitors of basic fibroblast growth factor (bFGF) induced pathways. Consistently, the  L.s.-1.25  fraction as well as  L.s.-P  successfully interfered with fibroblast binding to human bFGF. The incorporation of  L.s.-P  or  L.s.-1.25 , but not  L.s.-1.0  into Matrigel plugs containing melanoma cells induced a significant reduction in hemoglobin content as well in the frequency of tumor-associated blood vessels. Moreover,  i.p.  administrations of  L.s.-1.25 , as well as  L.s.-P , but not  L.s.-1.0 , resulted in a significant reduction of tumor growth when inoculated into syngeneic mice. Finally,  L.s.-1.25  markedly inhibited breast cancer cell adhesion to human platelet-coated surfaces. Thus, sulfated fucans are mainly responsible for the anti-inflammatory, anticoagulant, antiangiogenic, and antitumor activities of sulfated polysaccharides from  L. saccharina  brown seaweed.

Fucans, but Not Fucomannoglucuronans, Determine the Biological Activities of Sulfated Polysaccharides from Laminaria saccharina Brown Seaweed