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Background  Myelin transcription factor 1-like ( MYT1L ) is a member of the myelin transcription factor 1 ( MYT1 ) gene family, and the neural specific, zinc-finger-containing, DNA-binding protein that it encodes plays a role in the development of the nervous system. On the basis of a recent copy number variation (CNV) study showing that this gene is disrupted in mental disorder patients, we investigated whether  MYT1L  also plays a role in MDD.    Methods  In this study, 8 SNPs were analyzed in 1139 MDD patients and 1140 controls of Chinese Han origin.    Results  Statistically significant differences were noted between cases and controls for rs3748989 (allele: permutated p = 0.0079, corrected p = 0.0048, genotype: corrected p = 0.0204). A haplotype of rs1617213 and rs6759709 G-C was also significant (permutated p = 0.00007).    Conclusion  Our results indicate that  MYT1L  may be a potential risk gene for MDD in the Chinese Han population.

Common SNPs in Myelin Transcription Factor 1-Like (MYT1L): Association with Major Depressive Disorder in the Chinese Han Population