Open AccessA Genome-Wide Association Study of Red Blood Cell Traits Using the Electronic Medical Record
Author(s) -
Iftikhar J. Kullo,
Keyue Ding,
Hayan Jouni,
Carin Y. Smith,
Christopher G. Chute
Publication year - 2010
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0013011
Subject(s) - genome wide association study , mean corpuscular volume , mean corpuscular hemoglobin , hematocrit , single nucleotide polymorphism , mean corpuscular hemoglobin concentration , genetic association , biology , medicine , quantitative trait locus , red blood cell distribution width , genetics , genotype , gene
The Electronic Medical Record (EMR) is a potential source for high throughput phenotyping to conduct genome-wide association studies (GWAS), including those of medically relevant quantitative traits. We describe use of the Mayo Clinic EMR to conduct a GWAS of red blood cell (RBC) traits in a cohort of patients with peripheral arterial disease (PAD) and controls without PAD.
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