Open AccessFrequent MAGE Mutations in Human Melanoma
Author(s) -
Otávia L. Caballero,
Qi Zhao,
Donata Rimoldi,
Brian J. Stevenson,
Suzanne Svobodová,
Sylvie Devalle,
Ute F. Röhrig,
Anna Pagotto,
Olivier Michielin,
Daniel E. Speiser,
Jedd D. Wolchok,
Cailian Liu,
Tanja Pejović,
Kunle Odunsi,
Francis Brasseur,
Benoı̂t J. Van den Eynde,
Lloyd J. Old,
Xin Lü,
Jonathan Cebon,
Robert L. Strausberg,
Andrew J.G. Simpson
Publication year - 2010
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0012773
Subject(s) - melanoma , medicine , genetics , biology , computational biology
Cancer/testis (CT) genes are expressed only in the germ line and certain tumors and are most frequently located on the X-chromosome (the CT-X genes). Amongst the best studied CT-X genes are those encoding several MAGE protein families. The function of MAGE proteins is not well understood, but several have been shown to potentially influence the tumorigenic phenotype.
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