Open AccessParent-Of-Origin Effects in Autism Identified through Genome-Wide Linkage Analysis of 16,000 SNPs
Author(s) -
Delphine Fradin,
Keely CheslackPostava,
Christine LaddAcosta,
Craig J. Newschaffer,
Aravinda Chakravarti,
Dan E. Arking,
Andrew P. Feinberg,
M. Daniele Fallin
Publication year - 2010
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0012513
Subject(s) - autism , heritability of autism , genetics , genetic linkage , autism spectrum disorder , linkage (software) , single nucleotide polymorphism , neurodevelopmental disorder , genetic association , genome , genomic imprinting , biology , twin study , epigenetics , psychology , gene , dna methylation , genotype , developmental psychology , heritability , gene expression
Autism is a common heritable neurodevelopmental disorder with complex etiology. Several genome-wide linkage and association scans have been carried out to identify regions harboring genes related to autism or autism spectrum disorders, with mixed results. Given the overlap in autism features with genetic abnormalities known to be associated with imprinting, one possible reason for lack of consistency would be the influence of parent-of-origin effects that may mask the ability to detect linkage and association.
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