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Background  LIN-12/Notch signaling is important for cell-cell interactions during development, and mutations resulting in constitutive LIN-12/Notch signaling can cause cancer. Loss of negative regulators of  lin-12/Notch  activity has the potential for influencing cell fate decisions during development and the genesis or aggressiveness of cancer.    Methodology/Principal Findings  We describe two negative modulators of  lin-12  activity in  C. elegans . One gene,  sel-11 , was initially defined as a suppressor of a  lin-12  hypomorphic allele; the other gene,  cdc-42 , is a well-studied Rho GTPase. Here, we show that SEL-11 corresponds to yeast Hrd1p and mammalian Synoviolin. We also show that  cdc-42  has the genetic properties consistent with negative regulation of  lin-12  activity during vulval precursor cell fate specification.    Conclusions/Significance  Our results underscore the multiplicity of negative regulatory mechanisms that impact on  lin-12/Notch  activity and suggest novel mechanisms by which constitutive  lin-12/Notch  activity might be exacerbated in cancer.

sel-11 and cdc-42, Two Negative Modulators of LIN-12/Notch Activity in C. elegans