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Background    Math6/atoh8 , a bHLH transcription factor, is thought to be indispensable for early embryonic development and likely has important roles in vertebrate tissue-specific differentiation. However, the function of Atoh8 during early development is not clear because homozygous knockout causes embryonic lethality in mice. We have examined the effects of the  atoh8  gene on the differentiation of retina and skeletal muscle during early development in zebrafish.    Results  We isolated a  Math6  homologue in zebrafish, designated as zebrafish  atoh8 . Whole -mount  in situ  hybridization analysis showed that zebrafish  atoh8  is dynamically expressed mainly in developing retina and skeletal muscle. Atoh8-MO knock-down resulted in reduced eye size with disorganization of retinal lamination. The reduction of  atoh8  function also affected the arrangement of paraxial cells and differentiated muscle fibers during somite morphogenesis.    Conclusion  Our results show that Atoh8 is an important regulator for the development of both the retina and skeletal muscles necessary for neural retinal cell and myogenic differentiation during zebrafish embryogenesis.

Atoh8, a bHLH Transcription Factor, Is Required for the Development of Retina and Skeletal Muscle in Zebrafish