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Human naïve CD4 T cells express low levels of the immunomodulatory receptor CD300a, whereas effector/memory CD4 cells can be either CD300a +  or CD300a − . This suggested that CD300a expression could define a specific subset within the effector/memory CD4 T cell subpopulations. In fact,  ex vivo  analysis of the IFN-γ producing CD4 T cells showed that they are enriched in the CD300a +  subset. Moreover, stimulated CD4 T cells producing TNF-α and IL-2 besides IFN-γ (polyfunctional) are predominantly CD300a + . In addition to producing markedly higher levels of Th1-associated cytokines, the stimulated CD300a +  CD4 T cells are distinguished by a striking up-regulation of the T-box transcription factor eomesodermin (Eomes), whereas T-bet is up-regulated in both CD300a +  and CD300a −  activated CD4 T cells to similar levels. The pleiotropic cytokine TGF-β1 has a determinant role in dictating the development of this Th1 subset, as its presence inhibits the expression of CD300a and down-regulates the expression of Eomes and IFN-γ. We conclude that CD300a +  human Th1 cells tend to be polyfunctional and after stimulation up-regulate Eomes.

Human Th1 Cells That Express CD300a Are Polyfunctional and After Stimulation Up-Regulate the T-Box Transcription Factor Eomesodermin