English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The TRPM group of cation channels plays diverse roles ranging from sensory signaling to Mg 2+  homeostasis. In most metazoan organisms the TRPM subfamily is comprised of multiple members, including eight in humans. However, the  Drosophila  TRPM subfamily is unusual in that it consists of a single member. Currently, the functional requirements for this channel have not been reported. Here, we found that the  Drosophila  TRPM protein was expressed in the fly counterpart of mammalian kidneys, the Malpighian tubules, which function in the removal of electrolytes and toxic components from the hemolymph. We generated mutations in  trpm  and found that this resulted in shortening of the Malpighian tubules. In contrast to all other  Drosophila trp  mutations, loss of  trpm  was essential for viability, as  trpm  mutations resulted in pupal lethality. Supplementation of the diet with a high concentration of Mg 2+  exacerbated the phenotype, resulting in growth arrest during the larval period. Feeding high Mg 2+  also resulted in elevated Mg 2+  in the hemolymph, but had relatively little effect on cellular Mg 2+ . We conclude that loss of  Drosophila trpm  leads to hypermagnesemia due to a defect in removal of Mg 2+  from the hemolymph. These data provide the first evidence for a role for a  Drosophila  TRP channel in Mg 2+  homeostasis, and underscore a broad and evolutionarily conserved role for TRPM channels in Mg 2+  homeostasis.

Drosophila TRPM Channel Is Essential for the Control of Extracellular Magnesium Levels