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Chromosomal rearrangements involving the  EVI1  proto-oncogene are a recurrent finding in myeloid leukemias and are indicative of a poor prognosis. Rearrangements of the  EVI1  locus are often associated with monosomy 7 or cytogenetic detectable deletions of part of 7q. As  EVI1  overexpression alone is not sufficient to induce leukemia, loss of a 7q tumour suppressor gene might be a required cooperating event. To test this hypothesis, we performed high-resolution array comparative genomic hybridization analysis of twelve  EVI1  overexpressing patients and three  EVI1  deregulated cell lines to search for 7q submicroscopic deletions. This analysis lead to the delineation of two critical regions, one of 0.39 Mb on 7q35 containing the  CNTNAP2  gene and one of 1.33 Mb on chromosome bands 7q35–q36 comprising nine genes in  EVI1  deregulated cell lines. These findings open the way to further studies aimed at identifying the culprit  EVI1  implicated tumour suppressor genes on 7q.

Identification of Two Critically Deleted Regions within Chromosome Segment 7q35-q36 in EVI1 Deregulated Myeloid Leukemia Cell Lines