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Background: AQP1 belongs to aquaporins family, water-specific,membrane-channel proteins expressed in diverse tissues. Recent papers showedthat during angiogenesis, AQP1 is expressed preferentially by microvessels,favoring angiogenesis via the increase of permeability In particular, in AQP1null mice, endothelial cell migration is impaired without altering theirproliferation or adhesion. Therefore, AQP1 has been proposed as a novelpromoter of tumor angiogenesis. Methods/Findings: Using targeted silencing ofAQP1 gene expression, an impairment in the organization of F-actin and areduced migration capacity was demonstrated in human endothelial and melanomacell lines. Interestingly, we showed, for the first time, that AQP1co-immunoprecipitated with Lin-7. Lin7-GFP experiments confirmedco-immunoprecipitation. In addition, the knock down of AQP1 decreased the levelof expression of Lin-7 and b-catenin and the inhibition of proteasomecontrasted partially such a decrease. Conclusions/Significance: All together,our findings show that AQP1 plays a role inside the cells throughLin-7/b-catenin interaction. Such a role of AQP1 is the same in human melanomaand endothelial cells, suggesting that AQP1 plays a global physiological role.A model is presented.

AQP1 Is Not Only a Water Channel: It Contributes to Cell Migration through Lin7/Beta-Catenin