English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Background  The  INSIG2  rs7566605 and  PFKP  rs6602024 polymorphisms have been identified as obesity gene variants in genome-wide association (GWA) studies. However, replication has been contradictory for both variants. The aims of this study were to validate these obesity-associations through case-control studies and analyses of obesity-related quantitative traits. Moreover, since environmental and genetic factors may modulate the impact of a genetic variant, we wanted to perform such interaction analyses. We focused on physical activity as an environmental risk factor, and on the GWA identified obesity variants in  FTO  (rs9939609) and near  MC4R  (rs17782313) as genetic risk factors.    Materials and Methods  The four variants were genotyped in a combined study sample comprising a total of 18,014 subject ascertained from, the population-based Inter99 cohort ( n  = 6,514), the ADDITION screening cohort ( n  = 8,662), a population-based study sample ( n  = 680) and a type 2 diabetic patient group ( n  = 2,158) from Steno Diabetes Center.    Results  No association with overweight, obesity or obesity-related measures was shown for either the  INSIG2  rs7566605 or the  PFKP  rs6602024 variants. However, an interaction between the  INSIG2  rs7566605 variant and the level of self-reported physical activity ( p   Int  = 0.004) was observed. A BMI difference of 0.53 (SE 0.42) kg/m 2  was found when comparing physically passive homozygous C-allele carriers with physically passive G-allele carriers. No interactions between the two variants and  FTO  rs9939609 and  MC4R  rs17782313 were observed.    Conclusions  The  INSIG2  rs7566605 and  PFKP  rs6602024 polymorphisms play no apparent role in the development of common forms of obesity in the Danish population. However, if replicated, the  INSIG2  rs7566605 may influence the level of BMI in combination with the level of physical activity.

Non-Replication of Genome-Wide Based Associations between Common Variants in INSIG2 and PFKP and Obesity in Studies of 18,014 Danes