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Plasmodium falciparum  ( P. falciparum ) secretes hundreds of proteins—including major virulence proteins—into the host erythrocyte. In order to reach the host cytoplasm, most  P. falciparum  proteins contain an N terminal host-targeting (HT) motif composed of 11 amino acids.  In silico  analyses have suggested that the HT motif is conserved throughout the  Plasmodium  species but experimental evidence only exists for  P. falciparum . Here, we show that in the rodent malaria parasite  Plasmodium berghei  ( P. berghei ) a reporter-like green fluorescent protein expressed by the parasite can be exported to the erythrocyte cytoplasm in a HT-specific manner. This provides the first experimental proof that the HT motif can function as a signal for protein delivery to the erythrocyte across  Plasmodium  species. Further, it suggests that  P. berghei  may serve as a model for validation of  P. falciparum  secretome proteins. We also show that tubovesicular membranes extend from the vacuolar parasite into the erythrocyte cytoplasm and speculate that these structures may facilitate protein export to the erythrocyte.

A Plasmodium falciparum Host-Targeting Motif Functions in Export during Blood Stage Infection of the Rodent Malarial Parasite Plasmodium berghei