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Background  The development of the  Drosophila  eye imaginal disc requires complex epithelial rearrangements. Cells of the morphogenetic furrow are apically constricted and this leads to a physical indentation in the epithelium. Posterior to the furrow, cells start to rearrange into distinct clusters and eventually form a precisely patterned array of ommatidia. These morphogenetic processes include regulated changes of adhesion between cells.    Methodology/Principal Findings  Here, we show that two transmembrane adhesion proteins, Capricious and Tartan, have dynamic and complementary expression patterns in the eye imaginal disc. We also describe novel null mutations in  capricious  and double null mutations in  capricious  and  tartan . We report that they have redundant functions in regulating the architecture of the morphogenetic furrow and ommatidial spacing.    Conclusions/Significance  We conclude that Capricious and Tartan contribute to the adhesive properties of the cells in the morphogenetic furrow and that this regulated adhesion participates in the control of spacing ommatidial clusters.

Modulation of Drosophila Retinal Epithelial Integrity by the Adhesion Proteins Capricious and Tartan