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Background   Culex  species are widespread across Cameroon and responsible for high burden of nuisance in most urban settings. However, despite their high nuisance, they remain less studied compared to anophelines. The present study aimed to assess  Culex  species distribution, susceptibility to insecticide, bionomics and role in Lymphatic Filariasis (LF) transmission in the city of Yaoundé.    Methods  Mosquito collections were conducted from March to December 2017 using Centre for Disease Control light traps (CDC-LT), human landing catches (HLC) and larval collections. Mosquitoes were identified using morphological identification keys. Mosquitoes from the  Culex pipiens  complex were further identified using Polymerase Chain Reaction (PCR) to assess the presence of sibling species. Bioassays were conducted with 2–5 day-old unfed females to assess mosquito susceptibility to DDT, permethrin, deltamethrin and bendiocarb following WHO guidelines. Dead, control and surviving mosquitoes from bioassays were screened by PCR to detect the presence of knockdown resistance ( kdr ) alleles. Pools of mosquitoes were examined by PCR to detect the presence of  Wuchereria bancrofti .    Results  A total of 197,956 mosquitoes belonging to thirteen species were collected. The density of mosquito collected varied according to the collection methods, districts and seasons.  Culex quinquefasciatus  emerged as the most abundant and the only species of the  Culex pipiens  complex in Yaoundé.  Culex  species were found breeding in different types of breeding sites including polluted and unpolluted sites. All  Culex  species including  Cx antennatus ,  Cx duttoni ,  Cx perfuscus  and  Cx tigripes  were found to be highly resistant to permethrin, deltamethrin and DDT.  Culex quinquefasciatus  was also found to be resistant to bendiocarb. A high frequency of the West Africa  kdr  allele was recorded in resistant  Cx .  quinquefasciatus . Out of the 247 pooled samples of 25  Culex  spp. examined for the presence of  Wuchereria bancrofti , none was found infected.    Conclusion  The study confirms the high adaptation of Culex species particularly  Culex quinquefasciatus  to the urban environment and no implication of this species in the transmission of LF in Yaoundé Cameroon. Culex species predominance in urban settings highlight potential transmission risk of West Nile and rift valley fever in Yaoundé.

Culex species diversity, susceptibility to insecticides and role as potential vector of Lymphatic filariasis in the city of Yaoundé, Cameroon