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Leishmania  ( L .)  killicki  (syn.  L .  tropica ), which causes cutaneous leishmaniasis in Maghreb, was recently described in this region and identified as a subpopulation of  L .  tropica . The present genetic analysis was conducted to explore the spatio-temporal distribution of  L .  killicki  (syn.  L .  tropica ) and its transmission dynamics. To better understand the evolution of this parasite, its population structure was then compared with that of  L .  tropica  populations from Morocco. In total 198 samples including 85  L .  killicki  (syn.  L .  tropica ) (from Tunisia, Algeria and Libya) and 113  L .  tropica  specimens (all from Morocco) were tested. Theses samples were composed of 168  Leishmania  strains isolated from human skin lesions, 27 DNA samples from human skin lesion biopsies, two DNA samples from  Ctenodactylus gundi  bone marrow and one DNA sample from a  Phlebotomus sergenti  female. The sample was analyzed by using MultiLocus Enzyme Electrophoresis (MLEE) and MultiLocus Microsatellite Typing (MLMT) approaches. Analysis of the MLMT data support the hypothesis that  L .  killicki  (syn.  L .  tropica ) belongs to the  L .  tropica  complex, despite its strong genetic differentiation, and that it emerged from this taxon by a founder effect. Moreover, it revealed a strong structuring in  L .  killicki  (syn.  L .  tropica ) between Tunisia and Algeria and within the different Tunisian regions, suggesting low dispersion of  L .  killicki  (syn.  L .  tropica ) in space and time. Comparison of the  L .  tropica  (exclusively from Morocco) and  L .  killicki  (syn.  L .  tropica ) population structures revealed distinct genetic organizations, reflecting different epidemiological cycles.

Comparison of Leishmania killicki (syn. L. tropica) and Leishmania tropica Population Structure in Maghreb by Microsatellite Typing