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The evolutionary history and age of  Plasmodium vivax  has been inferred as both recent and ancient by several studies, mainly using mitochondrial genome diversity. Here we address the age of  P. vivax  on the Indian subcontinent using selectively neutral housekeeping genes and tandem repeat loci. Analysis of ten housekeeping genes revealed a substantial number of SNPs (n = 75) from 100  P. vivax  isolates collected from five geographical regions of India. Neutrality tests showed a majority of the housekeeping genes were selectively neutral, confirming the suitability of housekeeping genes for inferring the evolutionary history of  P. vivax . In addition, a genetic differentiation test using housekeeping gene polymorphism data showed a lack of geographical structuring between the five regions of India. The coalescence analysis of the time to the most recent common ancestor estimate yielded an ancient TMRCA (232,228 to 303,030 years) and long-term population history (79,235 to 104,008) of extant  P. vivax  on the Indian subcontinent. Analysis of 18 tandem repeat loci polymorphisms showed substantial allelic diversity and heterozygosity per locus, and analysis of potential bottlenecks revealed the signature of a stable  P. vivax  population, further corroborating our ancient age estimates. For the first time we report a comparable evolutionary history of  P. vivax  inferred by nuclear genetic markers (putative housekeeping genes) to that inferred from mitochondrial genome diversity.

plos neglected tropical diseases

Neutral Polymorphisms in Putative Housekeeping Genes and Tandem Repeats Unravels the Population Genetics and Evolutionary History of Plasmodium vivax in India