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Background    Toxocara canis  and  T. cati  are parasites of dogs and cats, respectively, that infect humans and cause human toxocariasis. Infection may cause asthma-like symptoms but is often asymptomatic and is associated with a marked eosinophilia. Previous epidemiological studies indicate that  T. canis  infection may be associated with the development of atopy and asthma.    Objectives  To investigate possible associations between  Toxocara  spp. seropositivity and atopy and childhood wheezing in a population of children living in non-affluent areas of a large Latin American city.    Methods  The study was conducted in the city of Salvador, Brazil. Data on wheezing symptoms were collected by questionnaire, and atopy was measured by the presence of aeroallergen-specific IgE (sIgE). Skin prick test (SPT), total IgE and peripheral eosinophilia were measured.  Toxocara  seropositivity was determined by the presence of anti- Toxocara  IgG antibodies, and intestinal helminth infections were determined by stool microscopy.    Findings  Children aged 4 to 11 years were studied, of whom 47% were seropositive for anti- Toxocara  IgG; eosinophilia >4% occurred in 74.2% and >10% in 25.4%; 59.6% had elevated levels of total IgE; 36.8% had sIgE≥0.70 kU/L and 30.4% had SPT for at least one aeroallergen; 22.4% had current wheezing symptoms. Anti- Toxocara  IgG was positively associated with elevated eosinophils counts, total IgE and the presence of specific IgE to aeroallergens but was inversely associated with skin prick test reactivity.    Conclusion  The prevalence of  Toxocara  seropositivity was high in the studied population of children living in conditions of poverty in urban Brazil.  Toxocara  infection, although associated with total IgE, sIgE and eosinophilia, may prevent the development of skin hypersensitivity to aeroallergens, possibly through increased polyclonal IgE and the induction of a modified Th2 immune reaction.

Toxocara Seropositivity, Atopy and Wheezing in Children Living in Poor Neighbourhoods in Urban Latin American