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This article describes considerations for the design and conduct of therapeutic trials in dengue. We have recommended a minimum set of clinical and laboratory endpoints in the belief that the field will benefit from a standardized reporting approach. Whilst clear challenges exist in developing therapies for dengue, not least the self-limiting nature of the virus infection, it is hoped that the clinical trial template described here will help accelerate the clinical testing of antiviral and other therapeutic candidates.

Therapeutics for Dengue: Recommendations for Design and Conduct of Early-Phase Clinical Trials