English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Schistosomiasis and opisthorchiasis are of public health importance in Southeast Asia. Praziquantel (PZQ) is the drug of choice for morbidity control but few dose comparisons have been made.    Methodology  Ninety-three schoolchildren were enrolled in an area of Lao PDR where  Schistosoma mekongi  and  Opisthorchis viverrini  coexist for a PZQ dose-comparison trial. Prevalence and intensity of infections were determined by a rigorous diagnostic effort (3 stool specimens, each examined with triplicate Kato-Katz) before and 28–30 days after treatment. Ninety children with full baseline data were randomized to receive PZQ: the 40 mg/kg standard single dose ( n  = 45) or a 75 mg/kg total dose (50 mg/kg+25 mg/kg, 4 hours apart;  n  = 45). Adverse events were assessed at 3 and 24 hours posttreatment.    Principal Findings  Baseline infection prevalence of  S. mekongi  and  O. viverrini  were 87.8% and 98.9%, respectively.  S. mekongi  cure rates were 75.0% (95% confidence interval (CI): 56.6–88.5%) and 80.8% (95% CI: 60.6–93.4%) for 40 mg/kg and 75 mg/kg PZQ, respectively ( P  = 0.60).  O. viverrini  cure rates were significantly different at 71.4% (95% CI: 53.4–84.4%) and 96.6% (95% CI: not defined), respectively ( P  = 0.009). Egg reduction rates (ERRs) against  O. viverrini  were very high for both doses (>99%), but slightly lower for  S. mekongi  at 40 mg/kg (96.4%  vs.  98.1%) and not influenced by increasing diagnostic effort.  O. viverrini  cure rates would have been overestimated and no statistical difference between doses found if efficacy was based on a minimum sampling effort (single Kato-Katz before and after treatment). Adverse events were common (96%), mainly mild with no significant differences between the two treatment groups.    Conclusions/Significance  Cure rate from the 75 mg/kg PZQ dose was more efficacious than 40 mg/kg against  O. viverrini  but not against  S. mekongi  infections, while ERRs were similar for both doses.    Trial Registration  Controlled-Trials.com  ISRCTN57714676

Efficacy of Praziquantel against Schistosoma mekongi and Opisthorchis viverrini: A Randomized, Single-Blinded Dose-Comparison Trial