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Scedosporium apiospermum  is part of the  Pseudallescheria-Scedosporium  complex. Peptidorhamnomannans (PRMs) are cell wall glycopeptides present in some fungi, and their structures have been characterized in  S. apiospermum ,  S. prolificans  and  Sporothrix schenckii . Prior work shows that PRMs can interact with host cells and that the glycopeptides are antigenic. In the present study, three monoclonal antibodies (mAbs, IgG1) to  S. apiospermum  derived PRM were generated and their effects on  S. apiospermum  were examined  in vitro  and  in vivo . The mAbs recognized a carbohydrate epitope on PRM. In culture, addition of the PRM mAbs increased  S. apiospermum  conidia germination and reduced conidial phagocytosis by J774.16 macrophages. In a murine infection model, mice treated with antibodies to PRM died prior to control animals. Thus, PRM is involved in morphogenesis and the binding of this glycopeptide by mAbs enhanced the virulence of the fungus. Further insights into the effects of these glycopeptides on the pathobiology of  S. apiospermum  may lead to new avenues for preventing and treating scedosporiosis.

Monoclonal Antibodies Against Peptidorhamnomannans of Scedosporium apiospermum Enhance the Pathogenicity of the Fungus