English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

MOB1 protein is a core component of the Hippo signaling pathway in animals where it is involved in controlling tissue growth and tumor suppression. Plant MOB1 proteins display high sequence homology to animal MOB1 proteins, but little is known regarding their role in plant growth and development. Herein we report the critical roles of  Arabidopsis MOB1  ( AtMOB1A ) in auxin-mediated development in  Arabidopsis . We found that loss-of-function mutations in  AtMOB1A  completely eliminated the formation of cotyledons when combined with mutations in  PINOID  ( PID ), which encodes a Ser/Thr protein kinase that participates in auxin signaling and transport. We showed that  atmob1a  was fully rescued by its  Drosophila  counterpart, suggesting functional conservation. The  atmob1a pid  double mutants phenocopied several well-characterized mutant combinations that are defective in auxin biosynthesis or transport. Moreover, we demonstrated that  atmob1a  greatly enhanced several other known auxin mutants, suggesting that  AtMOB1A  plays a key role in auxin-mediated plant development. The  atmob1a  single mutant displayed defects in early embryogenesis and had shorter root and smaller flowers than wild type plants.  AtMOB1A  is uniformly expressed in embryos and suspensor cells during embryogenesis, consistent with its role in embryo development. AtMOB1A protein is localized to nucleus, cytoplasm, and associated to plasma membrane, suggesting that it plays roles in these subcellular localizations. Furthermore, we showed that disruption of  AtMOB1A  led to a reduced sensitivity to exogenous auxin. Our results demonstrated that  AtMOB1A  plays an important role in  Arabidopsis  development by promoting auxin signaling.

NCP1/AtMOB1A Plays Key Roles in Auxin-Mediated Arabidopsis Development