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The extracellular matrix (ECM) is a pivotal component adult tissues and of many tissue-specific stem cell niches. It provides structural support and regulates niche signaling during tissue maintenance and regeneration. In many tissues, ECM remodeling depends on the regulation of MMP ( m atrix  m etallo p roteinase) activity by inhibitory TIMP ( t issue  i nhibitors of metalloproteinases) proteins. Here, we report that the only  Drosophila timp  gene is required for maintaining the normal organization and function of the germline stem cell niche in adult females.  timp  mutant ovaries show reduced levels of both  Drosophila  Collagen IV α chains. In addition, tissue stiffness and the cellular organization of the ovarian niche are affected in  timp  mutants. Finally, loss of  timp  impairs the ability of the germline stem cell niche to generate new cysts. Our results demonstrating a crucial role for  timp  in tissue organization and gamete production thus provide a link between the regulation of ECM metabolism and tissue homeostasis.

ECM-Regulator timp Is Required for Stem Cell Niche Organization and Cyst Production in the Drosophila Ovary