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In order to study the role played by cellular RNA pools produced by homologous genomic loci in defining the transcriptional state of a silenced gene, we tested the effect of non-functional alleles of the  white  gene in the presence of a functional copy of  white , silenced by heterochromatin. We found that non-functional alleles of  white , unable to produce a coding transcript, could reactivate  in trans  the expression of a wild type copy of the same gene silenced by heterochromatin. This new epigenetic phenomenon of transcriptional  trans -reactivation is heritable, relies on the presence of homologous RNA’s and is affected by mutations in genes involved in post-transcriptional gene silencing. Our data suggest a general new unexpected level of gene expression control mediated by homologous RNA molecules in the context of heterochromatic genes.

Trans-Reactivation: A New Epigenetic Phenomenon Underlying Transcriptional Reactivation of Silenced Genes