English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The BXD genetic reference population is a recombinant inbred panel descended from crosses between the C57BL/6 (B6) and DBA/2 (D2) strains of mice, which segregate for about 5 million sequence variants. Recently, some of these variants have been established with effects on general metabolic phenotypes such as glucose response and bone strength. Here we phenotype 43 BXD strains and observe they have large variation (∼5-fold) in their spontaneous activity during waking hours. QTL analyses indicate that ∼40% of this variance is attributable to a narrow locus containing the aryl hydrocarbon receptor ( Ahr ), a basic helix-loop-helix transcription factor with well-established roles in development and xenobiotic metabolism. Strains with the D2 allele of  Ahr  have reduced gene expression compared to those with the B6 allele, and have significantly higher spontaneous activity. This effect was also observed in B6 mice with a congenic D2  Ahr  interval, and in B6 mice with a humanized  AHR  allele which, like the D2 allele, is expressed much less and has less enzymatic activity than the B6 allele.  Ahr  is highly conserved in invertebrates, and strikingly inhibition of its orthologs in  D. melanogaster  and  C. elegans  ( spineless  and  ahr-1 ) leads to marked increases in basal activity. In mammals,  Ahr  has numerous ligands, but most are either non-selective (e.g. resveratrol) or highly toxic (e.g., 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)). Thus, we chose to examine a major environmental influence—long term feeding with high fat diet (HFD)—to see if the effects of  Ahr  are dependent on major metabolic differences. Interestingly, while HFD robustly halved movement across all strains, the QTL position and effects of  Ahr  remained unchanged, indicating that the effects are independent. The highly consistent effects of  Ahr  on movement indicate that changes in its constitutive activity have a role on spontaneous movement and may influence human behavior.

An Evolutionarily Conserved Role for the Aryl Hydrocarbon Receptor in the Regulation of Movement