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Commitment to mitosis is driven by activation of the Cdk1-Cyclin B protein kinase complex known as Mitosis Promoting Factor (MPF). MPF activation promotes downstream protein kinases that control the formation and function of the mitotic spindle. These kinases include members of the NIMA, Greatwall/Scant, Polo, and Aurora kinase families. Each kinase often phosphorylates multiple targets. Sophisticated dependency relationships enable a single kinase to promote distinct events at the same or successive stages of mitosis. Understanding mitosis means cataloguing each target for each kinase and deciphering the interplay between the ensuing pathways. Two papers in this issue of PLoS Genetics show that the ability of Greatwall/Scant kinase to generate an inhibitor of Protein Phosphatase 2A (PP2A) underpins an antagonistic interplay between Greatwall and Polo in Drosophila [1], [2].

Polo, Greatwall, and Protein Phosphatase PP2A Jostle for Pole Position