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David Botstein's name came up twice when the PLoS Genetics editors tossed around ideas for potential interviewees, and with good reason. First, he is now director of an exciting development on the Princeton University campus, the Lewis-Sigler Institute for Integrative Genomics, which weaves the physical, computational, and biological sciences into a cohesive endeavor. Second, his scientific discoveries have run the gamut of organisms, from phage P22 to yeast to humans. And third, David is no shrinking violet; he has a deeply held opinion about everything, and he isn't afraid to voice it.

Willing to Do the Math: An Interview with David Botstein