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Striatal projection neurons form a sparsely-connected inhibitory network, andthis arrangement may be essential for the appropriate temporal organization ofbehavior. Here we show that a simplified, sparse inhibitory network ofLeaky-Integrate-and-Fire neurons can reproduce some key features of striatalpopulation activity, as observed in brain slices [Carrillo-Reid et al., J.Neurophysiology 99 (2008) 1435{1450]. In particular we develop a new metric todetermine the conditions under which sparse inhibitory networks formanti-correlated cell assemblies with time-varying activity of individual cells.We found that under these conditions the network displays an input-specificsequence of cell assembly switching, that effectively discriminates similarinputs. Our results support the proposal [Ponzi and Wickens, PLoS Comp Biol 9(2013) e1002954] that GABAergic connections between striatal projection neuronsallow stimulus-selective, temporally-extended sequential activation of cellassemblies. Furthermore, we help to show how altered intrastriatal GABAergicsignaling may produce aberrant network-level information processing indisorders such as Parkinson's and Huntington's diseases.

Cell assembly dynamics of sparsely-connected inhibitory networks: a simple model for the collective activity of striatal projection neurons