English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Coherent angular rotation of epithelial cells is thought to contribute tomany vital physiological processes including tissue morphogenesis and glandularformation. However, factors regulating this motion, and the implications ofthis motion if perturbed remain incompletely understood. In the current study,we address these questions using a cell-center based model in which cells arepolarized, motile, and interact with the neighboring cells via harmonic forces.We demonstrate that, a simple evolution rule in which the polarization of anycell tends to orient with its velocity vector can induce coherent motion ingeometrically confined environments. In addition to recapitulating coherentrotational motion observed in experiments, our results also show the presenceof radial movements and tissue behavior that can vary between solid-like andfluid-like. We show that the pattern of coherent motion is dictated by thecombination of different physical parameters including number density, cellmotility, system size, bulk cell stiffness and stiffness of cell-celladhesions. We further observe that, perturbations in the form of cell divisioncan induce a reversal in the direction of motion when cell division occurssynchronously. Moreover, when the confinement is removed, we see that theexisting coherent motion leads to cell scattering, with bulk cell stiffness andstiffness of cell-cell contacts dictating the invasion pattern. In summary, ourstudy provides an in-depth understanding of the origin of coherent rotation inconfined tissues, and extracts useful insights into the influence of variousphysical parameters on the pattern of such movements

Coherent motion of monolayer sheets under confinement and its pathological implications