English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The set of regulatory interactions between genes, mediated by transcriptionfactors, forms a species' transcriptional regulatory network (TRN). Bycomparing this network with measured gene expression data one can identifyfunctional properties of the TRN and gain general insight into transcriptionalcontrol. We define the subnet of a node as the subgraph consisting of all nodestopologically downstream of the node, including itself. Using a large set ofmicroarray expression data of the bacterium Escherichia coli, we find that thegene expression in different subnets exhibits a structured pattern in responseto environmental changes and genotypic mutation. Subnets with less changes intheir expression pattern have a higher fraction of feed-forward loop motifs anda lower fraction of small RNA targets within them. Our study implies that theTRN consists of several scales of regulatory organization: 1) subnets with morevarying gene expression controlled by both transcription factors andpost-transcriptional RNA regulation, and 2) subnets with less varying geneexpression having more feed-forward loops and less post-transcriptional RNAregulation.

Patterns of subnet usage reveal distinct scales of regulation in the transcriptional regulatory network of Escherichia coli