Open AccessEffects of Anthocyanins on CAG Repeat Instability and Behaviour in Huntington’s Disease R6/1 Mice
Author(s) -
Linda Møllersen,
Olve Moldestad,
Alexander D. Rowe,
Anja Bjølgerud,
Ingunn Holm,
Linda Tveterås,
Arne Klungland,
Lars Retterstøl
Publication year - 2016
Publication title -
plos currents
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.282
H-Index - 49
ISSN - 2157-3999
DOI - 10.1371/currents.hd.58d04209ab6d5de0844db7ef5628ff67
Subject(s) - anthocyanin , huntington's disease , medicine , disease , biology , botany
Huntington's disease (HD) is a progressive neurodegenerative disorder caused by CAG repeat expansions in the HTT gene. Somatic repeat expansion in the R6/1 mouse model of HD depends on mismatch repair and is worsened by base excision repair initiated by the 7,8-dihydroxy-8-oxoguanine-DNA glycosylase (Ogg1) or Nei-like 1 (Neil1). Ogg1 and Neil1 repairs common oxidative lesions.
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