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Label-free imaging approaches seek to simplify and augment histopathologicassessment by replacing the current practice of staining by dyes to visualizetissue morphology with quantitative optical measurements. Quantitative phaseimaging (QPI) operates with visible/UV light and thus provides a resolutionmatched to current practice. Here we introduce and demonstrate confocal QPI forlabel-free imaging of tissue sections and assess its utility for manualhistopathologic inspection. Imaging cancerous and normal adjacent human breastand prostate, we show that tissue structural organization can be resolved withhigh spatial detail comparable to conventional H&E stains. Our confocal QPIimages are found to be free of halo, solving this common problem in QPI. Wefurther describe and apply a virtual imaging system based on Finite-DifferenceTime-Domain (FDTD) calculations to quantitatively compare confocal withwide-field QPI methods and explore performance limits using numerical tissuephantoms.

High-resolution label-free imaging of tissue morphology with confocal phase microscopy