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We report a new lensless microscopy configuration by integrating the conceptsof transverse translational ptychography and defocus multi-height phaseretrieval. In this approach, we place a tilted image sensor under the specimenfor linearly-increasing phase modulation along one lateral direction. Similarto the operation of ptychography, we laterally translate the specimen andacquire the diffraction images for reconstruction. Since the axial distancebetween the specimen and the sensor varies at different lateral positions,laterally translating the specimen effectively introduces defocus multi-heightmeasurements while eliminating axial scanning. Lateral translation furtherintroduces sub-pixel shift for pixel super-resolution imaging and naturallyexpands the field of view for rapid whole slide imaging. We show that theequivalent height variation can be precisely estimated from the lateral shiftof the specimen, thereby addressing the challenge of precise axial positioningin conventional multi-height phase retrieval. Using a sensor with a 1.67-micronpixel size, our low-cost and field-portable prototype can resolve 690-nmlinewidth on the resolution target. We show that a whole slide image of a bloodsmear with a 120-mm^2 field of view can be acquired in 18 seconds. We alsodemonstrate accurate automatic white blood cell counting from the recoveredimage. The reported approach may provide a turnkey solution for addressingpoint-of-care- and telemedicine-related challenges.

High-throughput lensless whole slide imaging via continuous height-varying modulation of tilted sensor