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While optical coherence tomography (OCT) provides a resolution down to 1micrometer it has difficulties to visualize cellular structures due to a lackof scattering contrast. By evaluating signal fluctuations, a significantcontrast enhancement was demonstrated using time-domain full-field OCT(FF-OCT), which makes cellular and subcellular structures visible. The putativecause of the dynamic OCT signal is ATP-dependent motion of cellular structuresin a sub-micrometer range, which provides histology-like contrast. Here wedemonstrate dynamic contrast with a scanning frequency-domain OCT (FD-OCT).Given the inherent sectional imaging geometry, scanning FD-OCT providesdepth-resolved images across tissue layers, a perspective known fromhistopathology, much faster and more efficiently than FF-OCT. Both, shorteracquisition times and tomographic depth-sectioning reduce the sensitivity ofdynamic contrast for bulk tissue motion artifacts and simplify their correctionin post-processing. The implementation of dynamic contrast makes microscopicFD-OCT a promising tool for histological analysis of unstained tissues.

Dynamic contrast in scanning microscopic OCT