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Intracellular lasers are emerging as powerful biosensors for multiplexedtracking and precision sensing of cells and their microenvironment. Thissensing capacity is enabled by quantifying their narrow-linewidth emissionspectra, which is presently challenging to do at high speeds. In this work, wedemonstrate rapid snapshot hyperspectral imaging of intracellular lasers. Usingintegral field mapping with a microlens array and a diffraction grating, weobtain images of the spatial and spectral intensity distribution from a singlecamera acquisition. We demonstrate widefield hyperspectral imaging over a3$\times$3 mm$^2$ field of view and volumetric imaging over250$\times$250$\times$800 $\mu$m$^3$ volumes with a spatial resolution of 5$\mu$m and a spectral resolution of less than 0.8 nm. We evaluate theperformance and outline the challenges and strengths of snapshot methods in thecontext of characterising the emission from intracellular lasers. This methodoffers new opportunities for a diverse range of applications, includinghigh-throughput and long-term biosensing with intracellular lasers.

Snapshot hyperspectral imaging of intracellular lasers