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Light scattering limits the penetration depth of non-invasive Ramanspectroscopy in biological media. While safe levels of irradiation may beadequate to analyze superficial tissue, scattering of the pump beam reduces theRaman signal to undetectable levels deeper within the tissue. Here wedemonstrate how wavefront shaping techniques can significantly increase theRaman signal at depth, while keeping the total irradiance constant, thusincreasing the amount of Raman signal available for detection.

Enhanced deep detection of Raman scattered light by wavefront shaping