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Diffuse optical tomography (DOT) reconstructs the images of internal optical parameter distribution using noninvasive boundary measurements. The image reconstruction procedure is known to be an ill-posed problem. In order to solve such a problem, a regularization technique is needed to constrain the solution space. In this study, a projection-error-based adaptive regularization (PAR) technique is proposed to improve the reconstructed image quality. Simulations are performed using a diffusion approximation model and the simulated results demonstrate that the PAR technique can improve reconstruction precision of object more effectively. The method is demonstrated to have low sensitivity to noise at various noise levels. Moreover, with the PAR method, the detectability of an object located both at the center and near the peripheral regions has been increased largely.

Improving image quality of diffuse optical tomography with a projection-error-based adaptive regularization method